Which symptom is not typically associated with Cushing's syndrome?

In the context of Cushing's syndrome, joint pain is not a hallmark symptom when compared to the other listed signs. Cushing's syndrome is characterized by excessive levels of cortisol, which leads to specific clinical manifestations related to metabolism, fat distribution, and blood pressure regulation. Symptoms such as the buffalo hump, which is the accumulation of fat between the shoulders, and moon facies, which refers to a rounded, plethoric appearance of the face, are directly related to the hormonal imbalance caused by increased cortisol. Hypertension also commonly occurs due to cortisol's effects on vascular tone and fluid balance.

In contrast, while joint pain can occur in various medical conditions, it is not a direct or typical manifestation of Cushing's syndrome, making it the least associated symptom among the options provided. Understanding the primary symptoms of disorders like Cushing's syndrome helps to differentiate them from other conditions that may present with joint pain, such as arthritis or other musculoskeletal disorders.