Which physical sign is characteristic of endocarditis?

Osler's nodes are small, painful nodules found on the pads of the fingers and toes and are a classic manifestation associated with infective endocarditis. They result from embolic phenomena, where infected material enters the bloodstream and lodges in the peripheral capillaries, leading to inflammation and the characteristic lesions.

Identifying Osler's nodes is significant as they are specific to endocarditis and can help in differential diagnosis. This sign, along with others such as Janeway lesions and splinter hemorrhages, contributes to the diagnosis of endocarditis, which is critical in managing the condition effectively.

Other physical signs related to endocarditis, such as murmurs or splenomegaly, may be present, but Osler's nodes are uniquely characteristic of the disease and can help in establishing a definitive diagnosis. The presence of a pericardial friction rub generally indicates pericarditis rather than endocarditis, which excludes it as a direct indicator.