Which of the following is NOT a common cause of peptic ulcer disease (PUD)?

The identified answer states that smoking is not a common cause of peptic ulcer disease (PUD). However, smoking is indeed recognized as a significant risk factor for the development of PUD. It contributes to the production of gastric acid and alters gastric mucosal defenses, facilitating ulcer formation.

The other options—excessive alcohol consumption, H. pylori infection, and NSAID usage—are well-established causes of peptic ulcers. Excessive alcohol consumption can irritate the gastric mucosa and amplify acid secretion. H. pylori infection is a bacterial infection that disrupts the balance of protective factors in the gastric mucosa, significantly contributing to ulcer development. NSAIDs, including aspirin and ibuprofen, inhibit the production of prostaglandins that protect the gastric lining, leading to an increased risk of ulceration.

In summary, smoking is indeed a recognized risk factor for PUD, while excessive alcohol, H. pylori, and NSAIDs are common culprits directly linked to its etiology.