Which of the following conditions is NOT typically treated with prednisone?

Prednisone is a corticosteroid commonly used to treat a variety of inflammatory and autoimmune conditions due to its ability to suppress the immune response and reduce inflammation.

In the case of asthma, rheumatoid arthritis, and inflammatory bowel disease, prednisone is often prescribed to manage exacerbations and control ongoing inflammation. These conditions are characterized by significant inflammatory processes where the anti-inflammatory effects of prednisone can provide substantial relief and improved symptom management.

On the other hand, diabetes mellitus is a metabolic disorder characterized by issues with insulin regulation and glucose metabolism. While patients with diabetes may experience complications or related inflammatory processes, prednisone is not typically used to treat diabetes itself. In fact, corticosteroids like prednisone can lead to increased blood glucose levels, making management of diabetes more challenging. Therefore, treating diabetes mellitus with prednisone is generally avoided, which is why it is the correct answer in this context.