Which adverse effect is associated with high doses of kava kava?

High doses of kava kava are primarily associated with adverse effects related to liver toxicity, but hypertension is a concern as well, particularly in individuals who may have underlying cardiovascular issues or those unaccustomed to its effects. Kava kava acts as a central nervous system depressant and can impact cardiovascular stability, potentially leading to increased blood pressure as a paradoxical effect in some individuals, especially when used in excess or in combination with other substances.

It is important to note that while dry skin, memory loss, and weight gain can be potential side effects of various substances, they are not specifically or primarily linked to high doses of kava kava as hypertension is. The hallmark effects of kava kava are largely due to its impact on neurotransmitter systems and its sedative properties, which highlight the importance of careful dosage and monitoring by healthcare providers to mitigate risks.