What is the most common clinical sign observed in CLL?

The most common clinical sign observed in Chronic Lymphocytic Leukemia (CLL) is enlarged lymph nodes. CLL is characterized by the proliferation of abnormal lymphocytes, which often accumulate in lymphoid tissues, leading to lymphadenopathy. Enlarged lymph nodes can be observed during physical examinations and may occur in multiple areas of the body, including the neck, axillae, and groin.

In CLL, while anemia, elevated white blood cell counts, and weight loss can occur, they are not as consistently present as lymphadenopathy. Lymph node enlargement is a hallmark of the disease and often serves as one of the primary indicators prompting further diagnostic evaluation. Therefore, when diagnosing CLL, healthcare providers frequently note the presence of enlarged lymph nodes as a critical sign of the condition.