What is a concerning side effect associated with selective serotonin reuptake inhibitors (SSRIs)?

QT prolongation is a concerning side effect associated with selective serotonin reuptake inhibitors (SSRIs), particularly with certain agents in this class, such as citalopram and escitalopram. QT prolongation refers to the lengthening of the QT interval on an electrocardiogram, which can lead to serious cardiac arrhythmias, including Torsades de Pointes. This effect can be particularly dangerous in older adults or those with existing cardiac issues, as it increases the risk of potentially fatal heart rhythm disturbances.

While weight gain, dry mouth, and drowsiness are also potential side effects of SSRIs, they are typically not as acute or significantly life-threatening as QT prolongation. These other side effects can impact a patient's quality of life or adherence to medication but do not generally pose the same immediate risk to cardiac health as QT prolongation does. Therefore, monitoring for QT interval changes is an important consideration when prescribing SSRIs, especially at higher doses or in patients with pre-existing cardiac conditions.