In cases of endocarditis, which physical sign may be observed?

Janeway lesions are characteristic physical findings associated with infective endocarditis. They present as non-tender macular or nodular lesions that can appear on the palms and soles. These lesions are a result of embolic events caused by the bacteria invading the heart valves, and they are specifically indicative of the infective process involving endocardial surfaces. The presence of Janeway lesions helps to differentiate infective endocarditis from other conditions that may present similarly, as they are not found in many other infections.

While high fever is commonly associated with endocarditis, it's a general systemic sign and is not specific to the condition. A pericardial friction rub indicates pericarditis, which is a different condition. Wheezing upon auscultation is more suggestive of respiratory issues rather than endocarditis. Therefore, the distinct nature of Janeway lesions makes them a key physical sign in identifying and diagnosing endocarditis in affected patients.