For which condition is gastric lavage with charcoal recommended?

Gastric lavage with activated charcoal is recommended primarily for the treatment of certain types of poisonings, particularly when the poison is ingested within a specific time frame and the substance is amenable to charcoal adsorption. In the case of organophosphate poisoning, gastric lavage can help remove residual poison from the stomach, and activated charcoal can absorb the organophosphate compounds, thereby preventing further absorption into the bloodstream.

This treatment is crucial in organophosphate poisoning because these compounds are often absorbed rapidly and can lead to severe toxicity, including central nervous system effects and muscarinic and nicotinic symptoms. Prompt intervention can significantly alter the clinical course and improve patient outcomes.

The other conditions mentioned do not benefit from gastric lavage with charcoal. Dermatological infections require topical or systemic antibiotics rather than gastrointestinal interventions, malignant melanoma treatment involves surgical excision and potentially systemic therapy like immunotherapy, and transplant rejection management typically includes immunosuppressive medications. Therefore, the focus for gastric lavage with charcoal is squarely on appropriately managing specific poisonings, such as organophosphate toxicity.